Genetic-Driven Druggable Target Identification and Validation

Published by Trends Genet.

Expression Quantitative Trait LocusTarget IdentificationGWAS AssociationGenetic Toolbox

This article reviews the opportunities and challenges, and infer criteria for the optimal use of genetic findings in the drug discovery pipeline. Choosing the right biological target is the critical primary decision for the development of new drugs. Systematic genetic association testing of both human diseases and quantitative traits, along with resultant findings of coincident associations between them, is becoming a powerful approach to infer drug targetable candidates and generate in vitro tests to identify compounds that can modulate them therapeutically

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