Children’s Cancer Research Institute Cell screening / clinical cell biology services

Provided by CCRI (Children's Cancer Research Institute)

ZANDR

Fluorescence-Activated Cell Sorting (FACS) Core Unit offers practical and theoretical support for all questions regarding flow cytometry. The laboratory presently has at its disposal three flow cytometers for 15 to 19 parameter cell measurements, one of which is a multi-colour device for cell sorting:
LSR II: 405, 488 & 635 nm lasers, 15 parameters
LSR Fortessa: 405, 488, 561 & 640 nm lasers, 19 parameters
FACSAriaFusion: 405, 488, 561 & 640 nm lasers, 19 parameters
Services also include: Cellular therapeutic agents for clinical routine, i.e.:
Cryopreservation and storage of, and storage logistics for autologous and allogeneic blood products
Thawing for reinfusion
CD3/19 depletion prior to HLA-mismatch stem cell transplantation
Cell manipulations and analyses for DLI
Preparation of MNC from blood for extracorporeal photopheresis (“mini ECP”) for treatment of GvHD

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Children’s Cancer Research Institute biological system modeling / bioinformatics services

Provided by CCRI (Children's Cancer Research Institute)

ZANDR

* Bioinformatics: The bioinformatics team provides advice and support for CCRI researchers with regard to analysis, integration and interpretation of large scale genomics datasets. We maintain and run computational pipelines for processing raw next-generation sequencing (NGS) data and data quality checks for all genomics data held within the CCRI/St.Anna Children´s Hospital. We are also performing high quality data analyses in close collaboration with CCRI/St.Anna Children´s Hospital researchers.

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Children’s Cancer Research Institute data management expertise services

Provided by CCRI (Children's Cancer Research Institute)

ZANDR

* Quality Management (support)
The QM always works in close cooperation with all staff members to provide cellular therapeutic agents, tissues, diagnostic services and study results of the highest quality and in compliance with legal requirements, guidelines and standards. This includes – but is not restricted to – support in the following respects:
Document management (writing, approval, distribution, version control, archiving, …)
Process management (recording of process flow diagrams, assignment of responsibilities, monitoring of process indicators, process enhancement, …)
Training and further education (conduct, management and refreshment of training)
Risk assessment and performance of risk analyses
Fault and deviation management (classification, allocation, processing and closing of errors, performance of root cause analyses and implementation of improvements)
Complaint handling
Supplier qualification (obtaining certificates or quality questionnaires, approval or blocking of suppliers, …)
Approval of maintenance, calibration and qualification reports for critical equipment
Method and process validation (defining and writing validation plans, calculating and representing results, writing validation reports, …)
Recording and reporting of side effects (pharmacovigilance, tissue vigilance, medical device vigilance)
Implementation of new standards
Auditing and monitoring including their reporting
Annual reporting (product quality reports, vigilance reports, management reports, and others)

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Children’s Cancer Research Institute marine model organisms services

Provided by CCRI (Children's Cancer Research Institute)

ZANDR

* Zebrafish platform Austria for Preclinical drug Screening (ZANDR) is a unique platform to phenotypically screen small compounds on zebrafish models of human diseases.
Zebrafish and in particular zebrafish larvae is a well suited vertebrate model system to investigate various human diseases and to perform cost-effective screens for small molecules with therapeutic potential (1). Funded by FFG, we have established a zebrafish-optimized and automated screening platform, which is open to the scientific community. Please contact us, if you are interested in collaboration: www.zandr-ccri.at

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